Recently I have read the article UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits, Deborah J. Thompson1. et al. Could I directly use the PRS in the phenotype in my study without calculating? If it makes sense, what population the PRS are applicable to, the whole ethnic group or only white? For instance, if I will study the association of heart disease, genetick risk and type 2 diabetes, may I use the enhanced t2d PRS scores in my model? Thanks.
I don't know the answer for this, but you may be interested to reach out to genomics PLC who generated this data and checkout their github https://github.com/Genomicsplc/ukb-pret
Thank you for your enquiry and for your interest in our work. Yes, you may indeed use our PRS scores (https://biobank.ndph.ox.ac.uk/ukb/label.cgi?id=300) for your own work. They do not require any calculation on your part - the Standard PRS scores have already been calculated on all individuals in UKB, and the Enhanced PRS score have already been calculated on all individuals in UKB who weren?t used for training for that set. They have been calculated for all ethnicities present in UK Biobank, using a method that allows them to be appropriately centred and scaled by genetically inferred ancestry (see the medRxiv paper you cite above for details: https://www.medrxiv.org/content/10.1101/2022.06.16.22276246v2). In order to use these PRS scores, you must be a registered and approved UKB researcher (see https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access).
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I don't know the answer for this, but you may be interested to reach out to genomics PLC who generated this data and checkout their github https://github.com/Genomicsplc/ukb-pret
Dear Yong Chen,
Thank you for your enquiry and for your interest in our work. Yes, you may indeed use our PRS scores (https://biobank.ndph.ox.ac.uk/ukb/label.cgi?id=300) for your own work. They do not require any calculation on your part - the Standard PRS scores have already been calculated on all individuals in UKB, and the Enhanced PRS score have already been calculated on all individuals in UKB who weren?t used for training for that set. They have been calculated for all ethnicities present in UK Biobank, using a method that allows them to be appropriately centred and scaled by genetically inferred ancestry (see the medRxiv paper you cite above for details: https://www.medrxiv.org/content/10.1101/2022.06.16.22276246v2). In order to use these PRS scores, you must be a registered and approved UKB researcher (see https://www.ukbiobank.ac.uk/enable-your-research/apply-for-access).
With kind regards,
Mike Weale and the Genomics plc team
Thanks for your reply, Prof Mike Weale. Your work is very helpful
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