Is HLA imputation available on RAP?

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2 comments

  • Comment author
    Chai Fungtammasan DNAnexus Team

    Everything that was available on Showcase should be available on RAP. It's a superset. If you find something missing, you can let us know, and we will fix it.

    For imputed HLA, it's in RAP for sure since I analyzed it for my research before. If your application doesn't include this, you can request.

    Note that you would also need this.

    wget -nd biobank.ctsu.ox.ac.uk/crystal/crystal/auxdata/ukb_hla_v2.txt

    This will give header for probability of each HLA in each sample.

     

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  • Comment author
    Sebastian Marcus May-Wilson

    Hi guys, apologies for necro-ing a 3-year old thread but I could use some advice on this topic as well.

    I have been trying to extract the HLA genotypes as a table on the RAP for an analysis. In order to do that I've been using the table exporter and have input a long version of the file that Chai Fungtammasan linked above (I.e. all fields in a column instead of in a row) as is required for the table exporter.

    Unfortunately, this has not worked using either of FIELD-NAME or FIELD-TITLE in the table exporter. And my understanding is that UKB-FORMAT has to be in pXX_iYY_aZZ format (which doesn't exist for the HLA columns).

    As such I am basically completely stumped with how to actually access the HLA genotypes for any downstream analyses.

    Any help here would be appreciated!

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