How to obtain Lp(a) values <3.8 and >189.0 nmol/L from Data Return 2321?

Pauline Schuitema

Dear UK Biobank team,

I am currently working with conventional lipoprotein(a) (Lp(a)) measurements in UK Biobank (Data-Field 30790, instance 0) within a dataset restricted to APOE ε2 homozygous individuals.

In this subset, approximately 27% of Lp(a) values are missing. Based on the assay documentation and the observed range (minimum 3.8 nmol/L), it appears that many of these missing values may represent results below or above the reportable range (<3.8 and >189.0 nmol/L), rather than true missing measurements. I would like to obtain the true out-of-range values from Data Return 2321.

In a recent publication (Morze J, Melloni GEM, Wittenbecher C, Ala-Korpela M, Rynkiewicz A, Guasch-Ferré M, Ruff CT, Hu FB, Sabatine MS, Marston NA. ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease. Eur Heart J. 2025;46(27):2691–2701), the authors state in the Supplementary Material that: “Values <3.8 and >189.0 nmol/L were acquired from Data Return 2321.”

However, after consulting the Showcase documentation and previous community posts regarding Return Data, I am still unclear how to access Data Return 2321 through the RAP environment or Table Exporter.

Could you please clarify:

  1. Whether Data Return 2321 is currently accessible via RAP?
  2. If so, what the correct procedure is to extract these Lp(a) values?

Access to these values is important for avoiding potential bias in analyses involving Lp(a), particularly in genotype-restricted subsets where low values are expected.

Many thanks in advance for your guidance.

Kind regards,
Pauline Schuitema

Comments

2 comments

Date Votes
  • Comment author
    Matt H The helpers that keep the community running smoothly. UKB Community team Access Team

    Dear Pauline 

    Thanks for your post. 

    Unfortunately, access to returned datasets is currently unavailable. We are currently developing a process that will enable researchers to access returned datasets for analysis via the Research Analysis Platform (RAP), but we do not yet have a date for when this will be active. 

    We appreciate your patience and understanding regarding the delays from the originally anticipated launch at the start of 2025. Please rest assured that we are working diligently to finalise this process. 

    Kind regards, 

    Matt

    0
  • Comment author
    Pauline Schuitema

    Dear Matt,

    Do you have any updates regarding the planned release of Data Return 2321?

    Kind regards,

    Pauline

    0

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