This page shows the timing of quantitative and binary traits of ~11 million variants. So, you can use this for estimating your ExWAS cases.
Please note that the timing used a computing system with 16 virtual CPU cores. So, your timing will also depend on the instance type you choose on RAP. Typically, you will get a faster timing with a system with better specs (i.e., more and faster cores and memory).
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Hi Catherine,
A recent study on ExWAS (https://www.nature.com/articles/s41586-021-04103-z) identified 12 million total variants of UKB exome data and performed the association analysis using Regenie.
As a start, here is a performance reference for Regenie:
https://rgcgithub.github.io/regenie/performance/
This page shows the timing of quantitative and binary traits of ~11 million variants. So, you can use this for estimating your ExWAS cases.
Please note that the timing used a computing system with 16 virtual CPU cores. So, your timing will also depend on the instance type you choose on RAP. Typically, you will get a faster timing with a system with better specs (i.e., more and faster cores and memory).
I hope this helps.
Regards,
Agung
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