Microsatellite sequences quality in UKBioBiank WGS

Marcin Wozniak
  • Edited

Hello!

I have a project in mind which would require analysis of some microsatelites' sequences. What is tha quality of such sequences in WGS data in the UKBB? Does the quality depend on the length of the repeat structure and the number of repeats in a given variant? For instance, I imagine that TH01 (https://www.ncbi.nlm.nih.gov/nuccore/NC_000011.10/?report=fasta&from=2171088&to=2171115) should be generally OK as even the longest variant is around 55bp but what about longer loci like ACTBP2 (https://www.ncbi.nlm.nih.gov/nuccore/NC_000006.12/?report=fasta&from=88277144&to=88277245) especially, when it comes to alleles with >35 repeats?

Do you have any experience with this kind of polymorphism in the UKBB WGS data?

Thanks in advance for any remarks

Marcin

 

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