Derivation of glucose-lactate measure
Hello,
I would like to use the variable glucose-lactate (Data-Field 20280) introduced in Phase 2, but I need to understand how it's calculated (i.e. the equation used) and why. I cannot see this information in the field description or documentation.
From looking at the numbers I believe the equation that was applied is glucose-lactate = glucose + 0.38 lactate, and I gather it is to take into account anaerobic glycolysis which would occur if sample measurements were to be delayed after preparation, but I want to be sure of these coefficients and understand where they come from.
Thank you.
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2 comments
Hi Marianne,
we do not currently have any further documentation about the glucose-lactate combination. The metabolomics data was provided by Nightingale Health, https://research.nightingalehealth.com/publications . We hope to have more information for you in the near future, at which point I aim to post again here. If you have not heard anything by the end of October 2024, you could consider contacting Nightingale directly using the “Contact us” link on their website.
Thank you for using the forum.
Hi Marianne,
we have received documentation from Nightingale about the glucose-lactate combination. Please see
https://research.nightingalehealth.com/uploads/documents/Nightingale-Health-glucose-lactate-biomarker-explained-Feb-2025-1.pdf
This link will be made available via UKB Showcase in due course.
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