Thouis R Jones
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Latest activity by Thouis R Jones
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Thouis R Jones commented,
Thanks for the idea, but there appear to be thousands of files in those directories which will take days to extract the variants. Is there a pre-existing list of passing variants, or a faster way ...
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Thouis R Jones commented,
Thanks. Unfortunately, PLINK2 filters donors first and then variants, so that requires creating a new set of variant files before running a GWAS. (https://www.cog-genomics.org/plink/2.0/order)I'm...
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Thouis R Jones commented,
Looking deeper at the per-variant missingness rates, this appears to be partly from the large relative size of the centromeric region (7% of the chromosome length) and the number of variants in tha...
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Thouis R Jones created a post,
High missingness in chromosome 18 DRAGEN WGS
When running QC with PLINK2 on DRAGEN WGS, I see a very large fraction of samples with high missingness, but only on chr18. Mean missingness is around 14%, and 99% of all donors that I'm looking a...
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