David Curtis

It matters a great deal what you are planning to do with the WGS data. I had a quick look at it and it seems quite daunting! Another user told me that if one doesn't get through all the money then ...

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• 09 January 2026 15:17
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Hi Danielle. I may have this wrong but I think what you would need to do is to submit a purchase order. If you do this then DNAnexus will raise an invoice. Then when it is paid the money is credite...

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• 09 January 2026 15:15
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UK Biobank should mediate the billing with DNA Nexus

The billing system is very unsatisfactory. It can be quite difficult to set up and then DNAnexus will not accept a purchase order for less than £10,000. The only alternative is to try to charge bil...

• David Curtis
• 09 January 2026 14:59
• 2 followers
• 1 comment
• 1 vote

Discrepancies between 200K and 270K WES datasets and with WGS data

It ooks like at least some exome genotype calls are very inaccurate indeed.I'm pasting below the genotype counts for two variants in the first 200K exomes and in the WGS data for the same subjects ...

• David Curtis
• 21 October 2024 10:52
• 2 followers
• 1 comment
• 0 votes

I've emailed Access about this but just to say here that it would be helpful if people were also able to download the index file for the exome pVCFs, which I think is called field_23157_pVCF_500k_E...

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• 02 October 2024 08:14
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I'm not sure how you're treating the WES data but if you're using individual variants (not gene-wise burdens) and if you only have variants in exons then I certainly wouldn't expect the AUC to be a...

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• 24 September 2024 18:07
• 1 vote

Can this command also be used within a virtual machine set up by Swiss Army Knife? So that the output would end up in the project space without being downloaded?I.e. I would run Swiss Army  Knife w...

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• 24 September 2024 18:00
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Thanks. This issue is being handled on the other thread https://community.ukbiobank.ac.uk/hc/en-gb/community/posts/17782930848029-Which-RAP-tools-work-natively-with-the-segmentation-of-the-genome-i...

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• 02 August 2024 15:59
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Ah, thanks, it looks like I need to “Dispense more data” to get the individual level VCFs. At the moment if I go to my project settings the “Check for updates” button is greyed out because it is "u...

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• 02 August 2024 15:51
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